Table 9

The four FMO VAPSEs with the best evolutionary conservation9-a

GeneI303TE339QP457LR502X
FMO1
 Human I 9-b ·· R 9-b
 Dog····
 Rat····
 Mouse····
 Rabbit····
FMO2
 HumanVD··
 MonkeyVD··
 Guinea PigV···
 RatVDN/AN/A
 MouseVD··
 RabbitV···
FMO3
 HumanV···
 MonkeyV···
 DogV···
 RatVD··
 MouseVD··
 RabbitVD··
 ChickenV···
FMO4
 HumanV E 9-b ··
 RatV···
 MouseV···
 RabbitV···
FMO5
 HumanVD P 9-b ·
 Guinea PigVD··
 MouseVD··
 RatVD··
FMO6
 HumanV···
  • 9-a  N/A, sequence not available; ·, identical sequence.

  • 9-b  The amino acid changed is in boldface. Thus, I303T and R502X occur in FMO1 whereas E339Q and P457L occur in FMO4 and 5, respectively.