Relative distribution of radioactivity (%) among various peaks in the radiochromatographic profiles of pooled urine from rat, dog, and human following oral administration of [14C]omapatrilat
| Metabolite3-a (Retention Time Range) | Pooled Urine Samples (% Distribution)3-b | ||
|---|---|---|---|
| Rat (0–48 h) | Dog (0–168 h) | Human (0–168 h) | |
| M1-a (13–14 min) | 25 | 16 | 14 |
| M1 (17–18 min) | 4 | 2 | 4 |
| M2 (19–20 min) | 63 | 32 | 25 |
| M3 (26–27 min) | –3-c | 7 | 8 |
| M4 (28–29 min) | – | – | 3 |
| M5 & M6 (30–32 min) | – | 1 | 4 |
| M7(32–33 min) | – | 1 | 3 |
| M8 (37–38 min) | – | 8 | 14 |
| M1-c(44–46 min) | 1 | – | – |
| M9 (51–52 min) | – | 11 | 17 |
| M10(57–58 min) | – | 15 | – |
| Others3-d | 4 | 5 | 5 |
| Total3-e | 97 | 98 | 97 |
↵3-a Structures of metabolites are shown in Fig. 7 except for metabolite M10, which was identified as the symmetrical disulfide of omapatrilat.
↵3-b Radioactive peaks are reported as a percentage of the total radioactivity eluted from the column after background subtraction. The recovery of the radioactivity from the column was quantitative.
↵3-c Percentages less than 1% are not reported.
↵3-d Radioactivity from peaks that have not been identified.
↵3-e Total is less than 100% because remainder of the radioactivity is distributed in small amounts (<0.5%) in various fractions throughout the radiochromatogram.