Table 4

Excretion of radioactivity following a single oral dose of14C-atomoxetine administered to beagle dogs

Time IntervalPercent of Radioactive Dose Excreted4-a
UrineFecesTotal4-b
h
0–60.01  ± 0.01—0.01  ± 0.01
6–1218.7  ± 9.5—18.7  ± 9.5
12–2415.7  ± 8.98.8  ± 8.24-c 24.4  ± 11.8
24–489.9  ± 2.326.4  ± 9.336.2  ± 9.7
48–723.8  ± 1.36.3  ± 1.610.1  ± 2.7
72–960.7  ± 0.21.0  ± 0.51.7  ± 0.6
Excreta Total48.7  ± 1.342.3  ± 5.591.1  ± 4.3

Data represents means + S.E.M. (n = 3 animals).

  • ↵4-a  Dogs received a 2 mg/kg (5 μCi/kg).

  • ↵4-b  Total includes radioactivity recovered in urine and feces.

  • ↵4-c  Represents radioactivity collected in feces from 0 to 24 h.