Pharmacokinetic parameters of PBN in Sprague-Dawley rats
| Route of Administration | AUC0–∞ ± S.D. | CLp± S.D. | Vdss ± S.D. | T1/2 ± S.D. |
|---|---|---|---|---|
| μg-h/ml | ml/min/kg | l/kg | h | |
| i.v. (10 mg/kg) | 13.95 ± 0.35 | 12.37 ± 3.82 | 1.74 ± 0.50 | 2.01 ± 0.35 |
| AUC0–∞ ± S.D. | Cmax ± S.D. | Tmax ± S.D. | T1/2 ± S.D. | ||
|---|---|---|---|---|---|
| μg-h/ml | μg/ml | h | h | % | |
| p.o. (20 mg/kg) | 23.89 ± 5.84 | 7.35 ± 1.92 | 0.56 ± 0.31 | 2.77 ± 0.55 | 85.63 |
| s.c. (30 mg/kg) | 15.96 ± 3.10 | 3.56 ± 0.66 | 0.81 ± 0.38 | 4.04 ± 0.55 | 38.13 |