Table 1

Mean pharmacokinetic parameters of etoricoxib following administration of a single 25-mg intravenous and 100-mg oral solution dose of [¹⁴C]etoricoxib to six healthy male volunteers

Route of Administration	Dose	AUC_∞^1-a	C_max^1-a	T_max^1-b	t_1/2^1-c	Clearance^1-a	V_dss^1-d	Bioavailability^1-e
	mg	μg · h/ml	ng/ml	h	h	ml/min	liter	%
i.v.	25	7.4 (2.1)			24.8 (6.9)	57 (16)	108 (26)
p.o.	100	24.4 (8.8)	1362 (333)	1.0 (0.5, 2.0)	24.9 (6.0)			83 (71, 97)

↵1-a Geometric mean (between-subject S.D.).
↵1-b Median (min, max).
↵1-c Harmonic mean (jackknife S.D.).
↵1-d Arithmetic mean (S.D.).
↵1-e Geometric mean (95% CI).