Metabolism of amprenavir by cDNA-expressed P450 isoforms
| M1 | M2 | M3 | M4 | M5 | Total | |
|---|---|---|---|---|---|---|
| Native Ad 293 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
| 1A1 | 0.11 | 0.23 | 0.25 | 0.03 | <0.01 | 0.62 |
| 1A2 | <0.01 | 0.02 | <0.01 | <0.01 | <0.01 | 0.02 |
| 2A6 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
| 2C8 | <0.01 | 0.02 | 0.03 | <0.01 | <0.01 | 0.05 |
| 2C9 | 0.18 | 0.95 | 0.10 | <0.01 | <0.01 | 1.23 |
| 2C18 | <0.01 | <0.01 | <0.01 | 0.05 | <0.01 | 0.05 |
| 2C19 | <0.01 | 0.05 | 0.05 | 0.02 | <0.01 | 0.12 |
| 3A4 | 0.40 | 1.44 | 3.78 | 0.21 | 0.13 | 7.19 |
| 3A5 | 0.29 | 1.06 | 0.81 | 0.07 | 0.01 | 2.24 |
| 3A7 | <0.01 | 0.13 | 0.48 | 0.02 | 0.01 | 0.64 |
Results are expressed in nanomoles formed in 24 h by 1 flask of cells.