Distribution of metabolites generated during in vitro incubation of amprenavir with human microsomes
| Microsomes | M1 | M2 | M3 | M4 | M5 | Total |
|---|---|---|---|---|---|---|
| Fetus | 0.3 | 0.3 | 0.75 | <0.15 | <0.15 | 1.35 |
| Neonate 1 day | <0.15 | 0.65 | 2.6 | 0.5 | <0.15 | 3.75 |
| Neonate 2 days | 1.6 | 4.75 | 3 | 1.4 | 1.25 | 12.0 |
| Infant 1 month | 0.6 | 7.6 | 8.2 | 3.0 | 3.3 | 22.7 |
| Infant 3 months | 1.8 | 23.2 | 21.7 | 9.4 | 13 | 69.2 |
| Adult 1 | 8 | 58.7 | 44.2 | 22.5 | 23.9 | 157.2 |
Results are expressed in picomoles formed in 1 min by 1 mg of microsomal protein in incubation performed in duplicate in one sample representative of its group of age.