Summary of immunohistochemical staining of CYP1A1 and CYP1B1 in mouse blood-brain interfaces2-a2-b
| Tissue | Treatment with AhR Agonist | Treatment with Vehicle | ||
|---|---|---|---|---|
| CYP1A1 | CYP1B1 | CYP1A1 | CYP1B1 | |
| Leptomeninges | ||||
| Vein endothelium | +++ | − | − | − |
| Artery endothelium | + | + | − | + |
| Artery smooth muscle | − | +++ | − | +++ |
| Choroid plexus | ||||
| Capillary endothelium | +++ | − | − | − |
| Epithelial cells | − | − | − | − |
| Brain vessels | ||||
| Capillary endothelium | − | − | − | − |
| Vein endothelium | +++ | − | − | − |
| Artery endothelium | + | + | − | + |
| Artery smooth muscle | − | +++ | − | +++ |
| Arteriol smooth muscle | − | +++ | − | +++ |
↵2-a +++ intense staining; ++ moderate staining; + weak staining; − no staining.
↵2-b Mice were pretreated with i.p. injections of BNF (80 mg/kg), PCB 126 (250 μg/kg) or corn oil (vehicle). The tissues were fixed and embedded in paraffin. Immunohistochemistry was performed using the avidin-biotin complex-technique.