Rats | Rats | Dogs | Humans | |
---|---|---|---|---|
n; gender | 4; M | 4; F | 4; 2 M, 2 F | 5 M |
Oral dose | 40 μmol/kg | 40 μmol/kg | 40 μmol/kg | 105 μmol |
Urine | 21.3 (1.9) | 16.5 (1.7) | 22.6 (2.4) | 25.2 (4.3) |
Feces | 71.3 (1.1) | 77.0 (2.0) | 66.9 (3.1) | 71.1 (4.5) |
Total2-a | 94.9 (1.5) | 96.6 (1.0) | 90.5 (2.2) | 96.3 (0.8) |
i.v. dose | 10 μmol/kg | 10 μmol/kg | 10 μmol/kg | |
Urine | 45.8 (3.5) | 34.6 (15.1) | 32.3 (1.3) | N.D. |
Feces | 37.4 (4.4) | 54.9 (8.7) | 57.9 (2.8) | N.D. |
Total2-a | 88.8 (0.9) | 96.0 (6.1) | 91.3 (1.6) | N.D. |
M, male; F, female; N.D., not determined as only unlabeled compound was given.
↵2-a Includes cage-wash.