Cumulative amounts of melagatran, ethyl-melagatran, and unknown metabolites excreted in feces following i.v. and oral administration of ximelagatran to rats, dogs, and humans (M, male; F, female; as determined using radiochemical detection methods)
| Route of Administration (i.v./oral) | Rats 4 (M) | Rats 4 (F) | Dogs 4 (2 M, 2 F) | Humans 5 (M) |
|---|---|---|---|---|
| Melagatran | ||||
| i.v. | 24.5 | 42.6 | 34.1 | N.D. |
| Oral | 35.9 | 43.5 | 37.8 | 33.6 |
| Ethyl-melagatran | ||||
| i.v. | 0.1 | 0.7 | 17.7 | N.D. |
| Oral | 20.6 | 23.1 | 21.1 | 21.2 |
| Unknown metabolites | ||||
| i.v. | 10.5 | 8.6 | 3.0 | N.D. |
| Oral | 9.1 | 8.4 | 11.0 | 14.7 |
Results are expressed as mean percentages of administered dose.
N.D., not determined as only unlabeled compound was given.