Species and Dose | Gender | n | Cmax | tmax | AUC | t | FMel |
---|---|---|---|---|---|---|---|
μmol/l | h | μmol · h/l | h | % | |||
Rat | |||||||
5 μmol/kg | M | 3 | 0.52 (0.15) | 0.14 (0.05) | 0.44 (0.10)a | 0.52 (0.07) | 9 (2) |
5 μmol/kg7-c | F | 5 | 0.59 | 0.17 | 0.60 | 0.72 | 13 |
10 μmol/kg | M | 4 | 1.72 (0.67) | 0.15 (0.04) | 1.86 (0.82) | 0.77 (0.13) | 20 (9) |
Dog | |||||||
5 μmol/kg | M/F | 4 | 0.46 (0.12) | 0.5 (0.0) | 3.00 (0.48)7-b | 19 (5) | 25 (4) |
10 μmol/kg | M/F | 4 | 2.14 (0.56) | 0.57 (0.13) | 8.51 (2.12) | 13 (5) | 36 (9) |
Human | |||||||
10 mg (21 μmol) | M | 5 | 0.15 (0.03) | 1.25 (0.18) | 1.05 (0.22) | 4.29 (0.53) | 43 (9) |