Table 1

Volume, flow, and other parameters for simulation of the area under the curves (AUC), metabolite formation (M), and bioavailability (F) of the intestine, which was viewed as three segments of each volume that received the proportional flow rate (no other clearance was assumed to exist, that is CLo = 0).

Segmental Traditional Model STMSegmental, Segregated Flow Model SSFM
Compartment volumes (ml)
  Reservoir,V R 200200
  Lumen,V lum (V lum1,V lum2,V lum3)2 (0.667)2 (0.667)
 Parameters for STM
  Intestinal blood volume,V int,b (V intb1,V intb2,V intb3)0.9 (0.3)
  Total intestinal tissue,V int (V int1,V int2,V int3)1.62 (0.54)
 Parameters for SSFM
  Serosa and other tissues,V s (V s1,V s2,V s3)1.458 (0.486)
  Enterocyte membrane layer,V en (V en1,V en2,V en3)0.162 (0.054)
  Blood volume to serosal layer,V sb (V sb1,V sb2,V sb3)0.81 (0.27)
  Blood volume to enterocyte layer,V en,b (V mb1,V mb2,V mb3)0.09 (0.03)
Flow Rate (ml/min)
 Total intestinal flow,Q int 88
 Flow to each intestinal segment, Q int,I 2.67
 Flow to enterocyte layer of segment, f Q Q int/31-a 0.267
 Flow to serosal layer of segment, (1 - f Q)Q int/31-b 2.4
  • 1-a The enterocyte layer received 10% of intestinal flow to the segment; the value of the volume term is unimportant in the simulation procedure.

  • 1-b The serosal layer received 90% of intestinal flow to the segment.