Table 2

Simulations for the STM with heterogeneous absorptive, metabolic, and secretory activities: effect of changing CLGIT, segmental absorption rate constant and intrinsic clearances for secretion and metabolism on the clearance (CL), systemic availability (F), and metabolite formation after p.o. (Mpo) and intravenous (Miv) administration.

Simulation NumberCLint,sec1CLint,sec2CLint,sec3CLint,m1CLint,m2CLint,m3ka1ka2ka3CLGIT= 0.01 ml/minCLGIT = 0.1 ml/min
CLiv2-aFMpo2-bMiv2-bCLiv2-aFMpo2-bMiv2-b
ml/min min −1
12460.50.50.53330.8530.57498.998.00.9310.57190.183.6
22460.50.50.53330.8490.57399.298.70.9070.57092.487.7
32460.50.50.53330.8460.57399.699.30.8790.57095.492.8
42460.50.50.51350.8490.57399.398.80.9020.56992.788.6
52460.50.50.51350.8470.57399.599.20.8860.56894.491.6
62460.50.50.51350.8450.57399.899.60.8670.57096.695.2
72460.50.50.55310.8700.57497.894.61.0220.57085.069.6
84440.50.50.55310.8620.57496.996.20.9830.56982.075.2
96420.50.50.55310.8530.57398.998.00.9300.56989.983.8
102460.10.50.93330.7530.86598.698.30.8320.81987.585.4
114440.10.50.93330.7530.86199.098.90.8370.79191.089.4
126420.10.50.93330.7540.85899.599.40.8360.76994.894.0
132460.10.50.91350.7550.85599.199.00.8450.75491.990.4
144440.10.50.91350.7610.84599.499.30.8450.75491.990.4
156420.10.50.91350.7660.83599.799.70.8780.68496.896.2
162460.10.50.95310.7620.86795.995.30.8840.83674.670.4
174440.10.50.95310.7580.86597.296.80.8710.81680.176.9
186420.10.50.95310.7550.86298.698.30.8490.79987.585.5
194440.90.50.11350.7450.43599.498.60.7750.48892.486.4
204440.90.50.13330.7530.43099.097.80.8370.45291.081.5
214440.90.50.15310.7810.42997.493.90.9810.44085.168.0
222460.90.50.11350.7510.43399.198.00.8230.47090.882.5
232460.90.50.13330.7610.42998.696.70.8900.44389.176.6
242460.90.50.15310.8000.42996.391.41.0480.43583.363.1
256420.90.50.11350.7390.43899.799.30.7230.50595.191.8
266420.90.50.13330.7460.43199.598.80.7730.46294.188.5
276420.90.50.15310.7600.43098.696.70.8800.44688.976.9

The CLd1 and CLd2 were 0.9 ml/min.

  • 2-a Values in ml/min.

  • 2-b Values as % dose.