Table 3

Simulations for the STM with heterogeneous absorptive, metabolic, and secretory activities: effect of changing CL_GIT, segmental absorption rate constant and intrinsic clearances for secretion and metabolism on the clearance (CL), systemic availability (F), and metabolite formation after po (M_po) and intravenous (Miv) administration.

Simulation Number	CL_int,sec1	CL_int,sec2	CL_int,sec3	CL_int,m1	CL_int,m2	CL_int,m3	k_a1	k_a2	k_a3	CL_GIT= 0.01 ml/min		CL_GIT = 0.1 ml/min
Simulation Number	CL_int,sec1	CL_int,sec2	CL_int,sec3	CL_int,m1	CL_int,m2	CL_int,m3	k_a1	k_a2	k_a3	CL_iv^3-a	F	M_po^3-b	M_iv^3-b	CL_iv^3-a	F	M_po^3-b	M_iv^3-b
	ml/min		min ⁻¹
1	2	4	6	0.5	0.5	0.5	3	3	3	1.208	0.808	98.4	98.0	1.371	0.807	86.6	83.6
2	2	4	6	0.5	0.5	0.5	3	3	3	1.202	0.808	98.9	98.7	1.317	0.807	90.2	88.0
3	2	4	6	0.5	0.5	0.5	3	3	3	1.195	0.808	99.5	99.3	1.259	0.807	94.3	93.2
4	2	4	6	0.5	0.5	0.5	1	3	5	1.200	0.807	99.0	98.8	1.306	0.806	90.9	88.9
5	2	4	6	0.5	0.5	0.5	1	3	5	1.196	0.807	99.4	99.2	1.271	0.805	93.4	92.0
6	2	4	6	0.5	0.5	0.5	1	3	5	1.193	0.807	99.7	99.6	1.233	0.806	96.2	95.5
7	2	4	6	0.5	0.5	0.5	5	3	1	1.244	0.808	96.9	94.5	1.615	0.807	79.0	67.4
8	4	4	4	0.5	0.5	0.5	5	3	1	1.226	0.808	95.5	96.2	1.502	0.806	73.6	74.3
9	6	4	2	0.5	0.5	0.5	5	3	1	1.208	0.808	98.4	98.0	1.368	0.806	86.8	83.9
10	2	4	6	0.1	0.5	0.9	3	3	3	1.125	0.953	98.3	98.2	1.276	0.940	85.2	84.4
11	4	4	4	0.1	0.5	0.9	3	3	3	1.122	0.952	98.8	98.8	1.247	0.934	89.4	88.8
12	6	4	2	0.1	0.5	0.9	3	3	3	1.119	0.951	99.4	99.4	1.214	0.928	94.0	93.7
13	2	4	6	0.1	0.5	0.9	1	3	5	1.122	0.950	98.9	98.9	1.247	0.917	90.4	89.8
14	4	4	4	0.1	0.5	0.9	1	3	5	1.123	0.948	99.3	99.3	1.249	0.905	93.3	92.9
15	6	4	2	0.1	0.5	0.9	1	3	5	1.124	0.946	99.6	99.6	1.243	0.896	96.3	96.1
16	2	4	6	0.1	0.5	0.9	5	3	1	1.152	0.954	95.0	94.8	1.464	0.945	69.3	67.7
17	4	4	4	0.1	0.5	0.9	5	3	1	1.140	0.953	96.6	96.5	1.382	0.941	76.3	75.0
18	6	4	2	0.1	0.5	0.9	5	3	1	1.126	0.953	98.3	98.2	1.285	0.937	85.4	84.7
19	4	4	4	0.9	0.5	0.1	1	3	5	1.112	0.704	99.3	99.0	1.161	0.730	92.4	89.9
20	4	4	4	0.9	0.5	0.1	3	3	3	1.122	0.702	98.8	98.3	1.247	0.712	89.4	85.3
21	4	4	4	0.9	0.5	0.1	5	3	1	1.157	0.701	96.7	95.3	1.160	0.715	93.7	91.4
22	2	4	6	0.9	0.5	0.1	1	3	5	1.119	0.703	98.9	98.5	1.227	0.723	89.9	86.3
23	2	4	6	0.9	0.5	0.1	3	3	3	1.131	0.701	98.3	97.5	1.328	0.709	86.0	80.4
24	2	4	6	0.9	0.5	0.1	5	3	1	1.182	0.701	95.2	93.2	1.651	0.705	74.5	64.0
25	6	4	2	0.9	0.5	0.1	1	3	5	1.104	0.705	99.6	99.5	1.095	0.737	95.5	94.2
26	6	4	2	0.9	0.5	0.1	3	3	3	1.112	0.702	99.4	99.2	1.160	0.715	93.7	91.4
27	6	4	2	0.9	0.5	0.1	5	3	1	1.131	0.701	98.3	97.5	1.315	0.709	86.2	80.8

The CL_d1 and CL_d2 were 10 ml/min.

↵3-a Values in ml/min.
↵3-b Values as % dose.