Table 2

Effect of LPS on the hepatic level of CYP mRNA in Stat1+/+ and Stat1−/−mice

1A22B102C292D92E13A114A10
Stat1+/+
 Controlb 1.00  ± 0.151.00  ± 0.621.00  ± 0.301.00  ± 0.181.00  ± 0.321.00  ± 0.311.00  ± 0.19
 LPS0.39  ± 0.08** 0.42  ± 0.180.26  ± 0.07** 0.89  ± 0.161.26  ± 0.280.22  ± 0.11** 3.38  ± 0.72**
Stat1−/−
 Control1.00  ± 0.171.00  ± 0.931.00  ± 0.121.00  ± 0.191.00  ± 0.171.00  ± 0.421.00  ± 0.33
 LPS0.26  ± 0.08** 0.29  ± 0.130.21  ± 0.07** 0.75  ± 0.280.86  ± 0.160.08  ± 0.04** 2.64  ± 0.50**

  • Values are the mean ± S.E. (n = 5 per group). Control group is used as a calibrator. ∗ P < 0.05, ∗∗ P < 0.01.