Effect of LPS on hepatic P450 activities in Stat+/+ and Stat1−/−mice
| Parameter | Stat1+/+ | Stat1−/− | ||
|---|---|---|---|---|
| Control | LPS | Control | LPS | |
| EROD3-a | 27.00 ± 4.30 | 20.00 ± 1.50* (73)3-d | 21.00 ± 2.30 | 20.00 ± 2.60 (95) |
| PROD3-a | 24.00 ± 3.90 | 20.00 ± 2.10* (84) | 27.00 ± 4.80 | 22.00 ± 3.10* (82) |
| 16α-OH-testosterone3-b | 0.71 ± 0.11 | 0.60 ± 0.01 (85) | 0.89 ± 0.01 | 0.74 ± 0.03*(83) |
| 6β-OH-testosterone3-b | 4.06 ± 0.72 | 1.80 ± 0.41** (44) | 5.02 ± 1.29 | 2.11 ± 0.43** (42) |
| 6-OH-chlorzoxazone3-b | 1.36 ± 0.19 | 1.04 ± 0.11* (76) | 1.51 ± 0.12 | 1.36 ± 0.18 (90) |
| 11-OH-LA3-c | 11.86 ± 1.46 | 8.54 ± 1.56* (72) | 10.29 ± 0.88 | 9.21 ± 1.78 (90) |
| 12-OH-LA3-c | 21.63 ± 2.24 | 15.34 ± 5.06* (71) | 19.58 ± 1.44 | 15.26 ± 3.09* (78) |
The assay conditions were described under Materials and Methods. Values are the mean ± S.E. (n = 5 per group).
↵3-a Expressed as picomoles per minute per milligram of protein.
↵3-b Expressed as nanomoles per minute per milligram of protein.
↵3-c Expressed as the percentage of the total CPM from the metabolites.
↵3-d Numbers in parentheses are the percentage of the corresponding controls.
3-178 P < 0.05 and ∗∗ P < 0.01 (significantly different from the corresponding controls).