Plasma | Brain | |||||
---|---|---|---|---|---|---|
H3-a | I3-b | IG3-c | H | I | IG | |
T max (h) | 1 | 1 | 0.5 | 1 | 0.5 | 0.5 |
C max(μg · mL−1) | 1.44 | 1.85 | 2.59 | 0.36 | 0.75 | 1.31 |
AUClast(h · μg · mL−1) | 5.93 | 6.29 | 6.41 | 0.95 | 2.49 | 3.89 |
AUC0–∞(h · μg · mL−1) | 6.41 | 6.47 | 7.15 | 1.17 | 2.58 | 4.0 |
(0.82)3-d | (0.90) | (0.85) | (0.15) | (0.34) | (0.51) | |
λz(L · h−1) | 0.32 | 0.25 | 0.42 | 0.33 | 0.43 | 0.37 |
t 1/2(h) | 2.20 | 1.65 | 2.72 | 2.09 | 1.62 | 1.88 |
CI/F(mL · h−1) | 46.8 | 46.4 | 41.9 | |||
V z/F(ml) | 148 | 164 | 110 |
↵3-a Infected mice treated with GF120918 (10 mg · kg−1) + Itraconazole (10 mg · kg−1).
↵3-b Infected mice treated with the placebo of GF120918 + Itraconazole (10 mg · kg−1).
↵3-c Healthy mice treated with the placebo of GF120918 + Itraconazole (10 mg · kg−1).
↵3-d Standard deviation calculated with the Bailer's method.