Apparent kinetic parameters for almotriptan biotransformation by human liver microsomes and mitochondria calculated by non-linear regression analysis of the untransformed data.
| Liver Fraction | Metabolite | ApparentKm | ApparentVmax | CLint |
|---|---|---|---|---|
| μM | pmol/min/mg | μl/min/mg | ||
| Microsomes | M2 | 102 (47)1-a | 40.1 (5) | 0.39 |
| M3 | 106 (35) | 95.1 (8) | 0.89 | |
| M4 | 434 (45) | 199.6 (12) | 0.46 | |
| M5 | 387 (86) | 56.0 (4) | 0.14 | |
| M6 | 387 (39) | 93.8 (6) | 0.24 | |
| M7 | 1245 (148) | 304.3 (19) | 0.24 | |
| Mitochondria | M6 | 62 (5) | 41.7 (1) | 0.67 |
| M7 | 363 (123) | 68.7 (19) | 0.19 |
↵1-a Values in parenthesis represent the standard error of measurement.