Table 2

Correlation of various P450-selective monooxygenase activities with the formation of almotriptan metabolites in a panel of human liver microsomes.

Table 2

The Spearman correlation coefficients were determined using liver tissue from 14 different organ donor subjects.

  • EROD, 7-ethoxyresorufin O-deethylation; COH, coumarin 7-hydroxylation; TOLH, tolbutamide methyl-hydroxylation; MEPH,S-mephenytoin 4'-hydroxylation; DEXOD, dextromethorphanO-demethylation; CHLH, chlorzoxazone 6-hydroxylation; DEXON, dextromethorphan N-demethylation; TSTH, testosterone 6β-hydroxylation; LAH: lauric acid 12-hydroxylation.

  • 2-178 p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.