Table 3

Metabolism of almotriptan in the presence of human B lymphoblastoid microsomes containing cDNA-expressed P450 proteins

Activity
IsoformM2M3M4M5M6M7
pmol/min/nmol P450
1A1N.D.3-a 124.3178.940.0N.D.87.2
1A2N.D.N.D.34.6N.D.N.D.N.D.
2A6N.D.N.D.N.D.N.D.N.D.N.D.
2B6N.D.N.D.N.D.N.D.N.D.N.D.
2C8N.D.N.D.23.4N.D.N.D.N.D.
2C9N.D.N.D.N.D.N.D.N.D.N.D.
2C19N.D.N.D.27.9N.D.N.D.N.D.
2D6N.D.88.432.1N.D.N.D.N.D.
2E1N.D.N.D.N.D.N.D.N.D.N.D.
3A4N.D.48.836.7N.D.N.D.N.D.
  • 3-a N.D., no activity detected.