Factors affecting resource demands and interest in drug metabolism research and training
| Decreased Interest | Increased Interest |
|---|---|
| • Opposition to animal subject experiments | • Importance of discovery ADME data |
| • Difficulty of human subject experiments | • Greater number of chemical leads |
| • Patent expirations and company mergers | • Metabolism as a basis for drug interactions and adverse events |
| • Pharmacokinetics requires mathematics | • In vitro model development and validation |
| • Lack of government research funding | • Role of transporters |
| • Metabolic pathways appear to be well-established | • In silico technologies |
| • Lack of exposure to drug metabolism principles during undergraduate and graduate courses | • Pharmacogenetics and clinical pharmacology |