Table 3

	Daunomycin (10 μmol/h/kg)		Taurocholate (400 pmol/h/kg)		E₂17 βG (160 pmol/h/kg)
	Normal	CCl₄-EHI_{24 h}	Normal	CCl₄-EHI_{24 h}	Normal	CCl₄-EHI_{24 h}
Plasma concentration (P)	2.30 ± 0.24 μM	2.00 ± 0.13 μM	0.288 ± 0.027 nM	0.350 ± 0.013 nM^3-150	0.151 ± 0.012 nM	0.263 ± 0.011 nM ^3-150
Liver concentration (L)	36.1 ± 3.3 μM	21.1 ± 4.0 μM^3-150	1.39 ± 0.30 nM	1.26 ± 0.13 nM	0.409 ± 0.12 nM	0.792 ± 0.19 nM^3-150
Biliary excretion rate	7.14 ± 0.79 nmol/min/kg	7.99 ± 1.5 nmol/min/kg	5.20 ± 0.62 pmol/min/kg	5.44 ± 1.2 pmol/min/kg	1.35 ± 0.15 pmol/min/kg	1.60 ± 0.13 pmol/min/kg
CL_exc(ml/min/kg)^3-b	0.198 ± 0.015	0.353 ± 0.061^3-150	3.74 ± 0.91	4.22 ± 0.64	3.57 ± 0.38	2.12 ± 0.49^3-150

Summary of the Effects of CCl₄ on the Pharmacokinetic Parameters of daunomycin, taurocholate, and E₂17 βG at steady-state conditions^a.

3-a All data represent the means ± S.D. (n = 6).
↵3-b CL_exc was calculated from dividing the excretion rate by the liver substrate concentration at the steady state.
↵3-150 Significantly different compared to normal rats (P< 0.01).