Effects of fluvoxamine on (S)-mephenytoin pharmacokinetic parameters in 12 subjects
| Phase | AUCinf | Terminalt1/2 | CLtot/F | Vd/F |
|---|---|---|---|---|
| μM · h | h | l/h | liters | |
| Control | 2.76 ± 1.36 | 2.5 ± 1.3 | 249 ± 222 | 759 ± 414 |
| Fluvoxamine 37.5 mg/day | 12.8 ± 14.3** | 5.9 ± 6.5** | 67.9 ± 52.9** | 341 ± 124** |
| Fluvoxamine 62.5 mg/day | 18.5 ± 17.6** | 7.4 ± 5.4** | 45.2 ± 47.6** | 322 ± 136** |
| Fluvoxamine 87.5 mg/day | 27.3 ± 25.1** | 11.3 ± 11.5** | 28.9 ± 19.4** | 338 ± 221** |
3-208 P < 0.01.