Pharmacokinetic parameters for FLINT and DcR3 in cynomolgus monkeys and CD-1 mice after subcutaneous administration 2-a
| DcR3 | FLINT | |||
|---|---|---|---|---|
| Mouse | Monkey | Mouse | Monkey | |
| Dose (mg/kg) | 0.5 | 1.0 | 0.5 | 1.0 |
| AUC (μg*h/ml) | 0.06 | 0.54 | 0.28 | 3.2 |
| C max(ng/ml) | 10.7 | 79.2 | 50.1 | 259.8 |
| T max (h) | 3.0 | 0.3 | 3.0 | 4.5 |
| T 1/2 (h) | 3.0 | 29.9 | 2.0 | 25.5 |
| %F | 12.5 | 5.8 | 77.8 | 21.9 |
AUC, area under the plasma concentration curve from zero to infinity; Cmax, maximal plasma concentration;Tmax, time to maximal plasma concentration;T1/2, elimination half-life; %F, absolute bioavailability.
↵2-a Plasma concentrations determined using an ELISA to full length FLINT or DcR3.