DcR3 | FLINT | |||
---|---|---|---|---|
Mouse | Monkey | Mouse | Monkey | |
Dose (mg/kg) | 0.5 | 1.0 | 0.5 | 1.0 |
AUC (μg*h/ml) | 0.11 (63%)3-b | 2.63 (83%)3-b | 0.019 (6.4%)3-b | 0.27 (7.7%)3-b |
C max (ng/ml) | 21.7 (67%)3-b | 162.2 (67%)3-b | 3.8 (7.1%)3-b | 19.8 (7.1%)3-b |
T max (h) | 3.0 | 6.0 | 3.0 | 4.5 |
T 1/2(h) | 0.6 | 9.7 | 0.8 | 48.7 |
AUC, area under the plasma concentration curve from zero to infinity; Cmax, maximal plasma concentration;Tmax, time to maximal plasma concentration;T1/2, elimination half-life; %F, absolute bioavailability.
↵3-a Plasma concentrations determined using an ELISA to DcR3(1–218).
↵3-b Percent of total AUC orCmax accounted for by DcR3(1–218) immunoreactivity; ie. AUCDcR3(1–218)/(AUCDcR3(1–218) + AUCfull length) × 100.