Table 1

Physiological parameters for calculation of intrinsic clearance in rats and humans

RatHuman
Number of hepatocytes/g liver (cells/g liver)120 × 106 120 × 106
Liver weight/kg body weight (g liver/kg)4025.7
Liver blood flow (ml/min/kg)55.220.7
  • Data from Bayliss et al. (1999) and Davies and Morris (1993).