| |
ml/min/kg body weight
| | | |
ml/min/kg body weight
| | | |
FK1052 | Rat | 8752-a
| 0.95 | 0.03 | 1.21 | 27,700 | 7,950 | 0.93 | Oxidation | In house data |
| Human | 26.42-a
| | 0.016 | 0.78 | 1,570 | 1,070 | 0.61 | | |
FK480 | Rat | 81.12-a
| 0.70 | 0.01 | 0.626 | 5,680 | 3,820 | 0.62 | Oxidation | In house data |
| Human | 2.42-a
| | 0.005 | 0.6 | 336 | 321 | 0.12 | | |
Diazepam | Rat | 103.82-a
| 1.00 | 0.137 | 1.04 | 758 | 496 | 0.64 | Oxidation |
Diaz-Garcia et al. (1992), Luurila et al. (1996), |
| Human | 0.72-a
| | 0.032 | 1.04 | 21.9 | 21.5 | 0.03 | |
Navia and Chaturvedi (1996), Sawada et al. (1985), Klotz et al. (1976)
|
Diltiazem | Rat | 300.22-a
| 1.00 | 0.184 | 0.93 | 1,630 | 685 | 0.85 | Oxidation |
Tsui et al. (1994), Kölle et al. (1983)
|
| Human | 64.22-a
| | 0.22 | 1.0 | 292 | 160 | 0.76 | |
Levet-Trafit et al. (1996), Lee et al. (1992), Piepho et al. (1982)
|
Quinotolast | Rat | 27.92-b
| 1.00 | 0.033 | 0.65 | 574 | 489 | 0.35 | Oxidation, glucuronidation |
Katashima et al. (1993a,b) |
| Human | 1.232-a
| | 0.0191 | 0.59 | 64.4 | 62.2 | 0.09 | |
Nakashima et al. (1993), in house data |
Troglitazone | Rat | 21.52-b
| 0.718 | 0.000921 | 0.594 | 67,800 | 43,700 | 0.66 | Glucuronidation, sulfation |
Izumi et al. (1996)
|
| Human | 13.12-a
| | 0.000941 | 0.548 | 10,000 | 7,910 | 0.45 | | |
FK079 | Rat | 1.642-b
| 1.00 | 0.060 | 0.63 | 28.8 | 28.3 | 0.05 | Oxidation, hydrolysis |
Tokuda et al. (1997)
|
| Human | 10.822-a
| | 0.017 | 0.59 | 636 | 497 | 0.22 | | |
Zidovudine | Rat | 40.672-b
| 1.00 | 0.786 | 1.0 | 20.2 | 18.4 | 0.22 | Glucuronidation, oxidation |
Mays et al., (1991), de Miranda et al., (1990)
|
| Human | 39.122-a
| | 0.8 | 0.98 | 42.1 | 28.4 | 0.62 | |
Yazdanian et al. (1998), Blum et al., (1988), Collins and Unadkat, (1989), Hedaya et al., (1990)
|
Acetaminophen | Rat | 23.82-b
| 1.00 | 0.82 | 1.0 | 51.0 | 41.0 | 0.43 | Glucuronidation, sulfation |
Hjelle and Klaassen, (1984), Koss et al., (1970)
|
| Human | 4.652-b
| | 0.79 | 1.0 | 6.71 | 6.17 | 0.20 | |
Gazzard et al. (1973), Chiou and Barve (1998), Sonne et al. (1988), Lin and Levy (1986)
|