Table 3

Estimation of rat CL_{int,in vitro} in freshly isolated hepatocytes and their scaling factor values for the model compounds

Compounds	CL_{int,in vitro}^3-a	Scaling Factor (CL_{int,in vivo}/CL_{int,in vitro})
Compounds	CL_{int,in vitro}^3-a	Well Stirred	Dispersion
	ml/min/kg body weight
FK1052	635 ± 24	43.6	12.5
FK480	226 ± 13	25.1	16.9
Diazepam	345 ± 39	2.2	1.4
Diltiazem	3300 ± 1330	0.5	0.2
Quinotolast	54.6 ± 3.4	10.5	9.0
Troglitazone	928 ± 9	73.1	47.1
FK079	4.75 ± 0.14	6.1	6.0
Zidovudine	14.3 ± 1.0	1.4	1.3
Acetaminophen	71.3 ± 10.9	0.7	0.6