Table 4

Binding of the model compounds to rat freshly isolated hepatocytes and their effects on the values of rat scaling factor

Compoundsfu,hepatocytesRat CLuint,in vitroRat Scaling Factor
Well StirredDispersion
ml/min/kg
FK10520.244260010.73.1
FK4800.20211205.13.4
Diazepam0.7054891.61.0
Diltiazem0.52962400.30.1
Quinotolast0.93758.39.88.4
Troglitazone0.217428015.810.2
FK0790.7136.664.34.2
Zidovudine1.00014.31.41.3
Acetaminophen0.93376.40.70.5