No Corrections | Corrected with Rat Scaling Factor | ||||||
---|---|---|---|---|---|---|---|
Compounds | Predicted CLint,in vivo | Observed CLint,in vivo/ Predicted CLint,in vivo | Predicted CLint,in vivo | Observed CLint,in vivo/Predicted CLint,in vivo | |||
Well Stirred | Dispersion | Well Stirred | Dispersion | Well Stirred | Dispersion | ||
ml/min/kg | ml/min/kg | ||||||
FK1052 | 7.89 | 199.0 | 135.6 | 344 | 98.6 | 4.6 | 10.9 |
FK480 | 9.98 | 33.7 | 32.2 | 250 | 169 | 1.3 | 1.9 |
Diazepam | 4.14 | 5.3 | 5.2 | 9.1 | 5.8 | 2.4 | 3.7 |
Diltiazem | 72.4 | 4.0 | 2.2 | 36.2 | 14.5 | 8.1 | 11.0 |
Troglitazone | 67.4 | 148.4 | 117.4 | 4930 | 3170 | 2.0 | 2.5 |
FK079 | 40.2 | 15.8 | 12.4 | 245 | 241 | 2.6 | 2.1 |
Zidovudine | 9.87 | 4.3 | 2.9 | 13.8 | 12.8 | 3.1 | 2.2 |
Acetaminophen | 2.39 | 2.8 | 2.6 | 1.67 | 1.43 | 4.0 | 4.3 |