Table 5

Predicted CLint,in vivo and the differences between observed and predicted CLint,in vivo

No CorrectionsCorrected with Rat Scaling Factor
CompoundsPredicted CLint,in vivoObserved CLint,in vivo/ Predicted CLint,in vivoPredicted CLint,in vivoObserved CLint,in vivo/Predicted CLint,in vivo
Well StirredDispersionWell StirredDispersionWell StirredDispersion
ml/min/kg ml/min/kg
FK10527.89199.0135.634498.64.610.9
FK4809.9833.732.22501691.31.9
Diazepam4.145.35.29.15.82.43.7
Diltiazem72.44.02.236.214.58.111.0
Troglitazone67.4148.4117.4493031702.02.5
FK07940.215.812.42452412.62.1
Zidovudine9.874.32.913.812.83.12.2
Acetaminophen2.392.82.61.671.434.04.3