Table 4

Metabolite identification following the CYP2D6 mediated oxidation of candidate N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines

graphic

  • 4-a  Rt corresponds to the retention time of the individual metabolites.

  • 4-b  In the case of the pyridinium metabolites, authentic standards were available.

  • 4-c  The protonated iminium fragments are also common to the parent tetrahydropyridine.