Table 4

K_i values for fluoxetine, ezlopitant, imipramine, and quinidine on CYP2D6 catalyzed bufuralol 1′-hydroxylase activity based on total (nominal) and free inhibitor and substrate concentrations

Microsomal Protein Concentration	Fluoxetine		Ezlopitant		Imipramine		Quinidine
Microsomal Protein Concentration	Nominal	Free	Nominal	Free	Nominal	Free	Nominal	Free
	μM
Control (0.0088 mg/ml)	0.048	0.033	0.034	0.0016	0.39	0.30	0.0010	0.00078
0.2 mg/ml	0.16	0.025	0.22	0.0093	0.71	0.33	0.0016	0.0012
2.0 mg/ml	1.7	0.043	1.3	0.0039	4.1	0.95	0.0038	0.0017