Table 2

Correlation of voriconazole N-oxidation and P450 activities (using log data for both) across a bank of human liver microsomes (determinations were n = 4 for each liver)

P450 (Substrate)25 μM Voriconazole2500 μM Voriconazole
CYP1A2 (caffeine)0.590.48
CYP2A6 (coumarin)0.530.65
CYP2C9 (S-warfarin)0.530.43
CYP2C19 (S-mephenytoin)0.770.47
CYP2D6 (bufuralol)0.340.45
CYP2E1 (p-nitrophenol)0.450.47
CYP3A4 (testosterone)0.740.90