In vitro percutaneous absorption of different doses of neat [14C]NMP into full-thickness skin of male rats
| Weight of Rat (g) | 25 μl/cm2 (n = 6) | 50 μl/cm2 (n = 6) | 100 μl/cm2 (n = 4) | 200 μl/cm2 (n = 7) | 400 μl/cm2 (n = 16) |
|---|---|---|---|---|---|
| 240 ± 9 | 240 ± 9 | 265 ± 15 | 247 ± 8 | 262 ± 11 | |
| Thickness (mm) | 1.35 ± 0.03 | 1.23 ± 0.05 | 1.44 ± 0.09 | 1.28 ± 0.06 | 1.29 ± 0.03 |
| Unabsorbed dose (percentage of the dose) | 9.5 ± 2.7 | 10.8 ± 2.3 | 32.5 ± 1.1 | 47.0 ± 3.4 | |
| Skin (mg/cm2) | 4.3 ± 1.1 | 6.0 ± 0.8 | 37.7 ± 2.84-a | 18.7 ± 3.7 | 28.1 ± 1.8 |
| Recovery (percentage of the dose) | 88.1 ± .08 | 86.6 ± 1.0 | 88.8 ± 0.8 | 84.2 ± 4.1 | 89.5 ± 1.7 |
| F max Nor (mg/cm2/h) | 2.1 ± 0.1 | 3.4 ± 0.1 | 5.3 ± 0.3 | 6.4 ± 0.3 | 7.5 ± 0.2 |
| T max(h) | 1.9 ± 0.2 | 2.2 ± 0.1 | 3.4 ± 0.2 | 3.9 ± 0.3 | 6.1 ± 0.3 |
Values are given as mean ± S.E.M. Increasing volumes of neat [14C]NMP were deposited on full thickness skin of male rats. For each rat, a piece of haunch and shoulder was treated with the same volume of NMP.
↵4-a Percentage of the dose in the unabsorbed fraction and in the skin.