Parameters | Control (n = 9) | U-ARF (n = 9) |
---|---|---|
Body weight (g) | 304 ± 19.2 | 293 ± 8.86 |
CZX | ||
Terminal half-life (min) | 32.0 ± 12.6 | 18.8 ± 8.40* |
AUC (μg · min/ml) | 2230 ± 837 | 1130 ± 239* |
MRT (min) | 44.2 ± 20.8 | 20.9 ± 7.59* |
CL (ml/min/kg) | 8.96 ± 3.14 | 17.8 ± 4.43* |
Vss (ml/kg) | 373 ± 90.9 | 344 ± 98.0 |
OH-CZX | ||
Terminal half-life (min) | 39.5 ± 5.95 | 135 ± 58.7** |
AUC (μg · min/ml) | 834 ± 74.4 | 8520 ± 4090** |
GI0-8 h (% of an i.v. dose) | 0.583 ± 0.148 | 1.81 ± 0.121** |