TABLE 3

Distribution of[¹⁴C]aprepitant and its metabolites in plasma and brain of ferrets dosed orally with 3 mg/kg

Ferret	Time	Total Radioactivity					Total Radioactivity as Aprepitant^a
Ferret	Time			Plasma	Brain	Brain-to-Plasma Ratio	Plasma	Brain	Brain-to-Plasma Ratio
	h	ng Eq/ml	ng Eq/g tissue		ng Eq/ml	ng Eq/g tissue
1	24	610	469	0.77	586	375	0.64
2	24	570	460	0.81	487	324	0.67
3	48	393	370	0.94	362	229	0.63
4	48	493	332	0.67	360	227	0.63

↵ ^a Estimated from chromatographic profile, as described under Materials and Methods. Two ferrets were used at each time point