Ferret | Time | Total Radioactivity | Total Radioactivity as Aprepitanta | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Plasma | Brain | Brain-to-Plasma Ratio | Plasma | Brain | Brain-to-Plasma Ratio | ||||||
h | ng Eq/ml | ng Eq/g tissue | ng Eq/ml | ng Eq/g tissue | |||||||
1 | 24 | 610 | 469 | 0.77 | 586 | 375 | 0.64 | ||||
2 | 24 | 570 | 460 | 0.81 | 487 | 324 | 0.67 | ||||
3 | 48 | 393 | 370 | 0.94 | 362 | 229 | 0.63 | ||||
4 | 48 | 493 | 332 | 0.67 | 360 | 227 | 0.63 |
↵ a Estimated from chromatographic profile, as described under Materials and Methods. Two ferrets were used at each time point