TABLE 10

Weak CYP3A inhibitors (oral midazolam used as probe substrate)


Drug

Dose/Regimen

Midazolam Dose

Fold Elevation in Midazolam AUC (GMR)

Reference
Grapefruit juice 200 ml, normal strength, 1 h before 15 mg p.o. 1.5 Kupferschmidt et al., 1995
Roxithromycin 300 mg q.d. × 6 days 15 mg p.o. 1.5 Backman et al., 1994a (Versed package circular, 2001)
Fentanyl
200 μg with nitrous oxide and isoflurane/(n = 15/group)
0.2 mg/kg p.o.
1.4
Hase et al., 1997