Drug | Dose/Regimen | Midazolam Dose | Fold Elevation in Midazolam AUC (GMR) | Reference |
---|---|---|---|---|
Azithromycin | 400 mg q.d. × 3 days | 15 mg p.o. | 1.3 | Zimmermann et al., 1996 |
Cimetidine | 800 mg p.o. × 1 day | Not noted | 1.3 | Fee et al., 1987 |
Simvastatin | 80 mg q.d. × 7 days | 2 mg p.o. | 1.1 | Prueksaritanont et al., 2000 |
Fluoxetine | 60 mg q.d. × 5 days, then 20 mg/day | Not specified | 0.8 | Lam et al., 1999 |
Rifampicin | 600 mg q.d. × 5 days | 15 mg p.o. | 0.023 | Backman et al., 1998 |
Azithromycin | 500 mg q.d. × 3 days | 15 mg p.o. | NSDa | Yeates et al., 1996 |
Terbinafine | 250 mg q.d. × 4 days | 7.5 mg p.o. | NSD | Olkkola et al., 1994 |
Azithromycin
|
500 mg day 1250 mg days 2-5
|
15 mg p.o. days
|
NSD
|
Backman et al., 1995
|
↵ a NSD, no significant difference in midazolam plasma AUC, with vs. without the interacting drug (GMR ≅ 1.0).