Species and Route of Administration | Dose | Urine Excretion (0-120 h) | Feces Excretion (0-120 h) | Total Excretion | ||
---|---|---|---|---|---|---|
0-48 h | 0-120 h | |||||
mg/kg | ||||||
Male mouse (n = 3), oral | 30 | 45.1 | 52.5 | 95.3 | 98.3 | |
Male rat (n = 3), i.v. | 10 | 66.0 | 37.2 | 103.2 | 105.1 | |
Male rat (n = 3), oral | 30 | 67.1 | 31.8 | 98.9 | 101.1 | |
Female rat (n = 3), i.v. | 10 | 78.2 | 25.8 | 104.0 | 106.0 | |
Female rat (n = 3), oral | 30 | 74.6 | 22.9 | 97.5 | 99.8 | |
Female rabbit (n = 3), i.v. | 10 | 87.2 | 6.9 | 94.1 | 94.4 | |
Female guinea pig (n = 3), oral | 10 | 37.4 | 54.4 | 91.8 | 93.9 | |
Male dog (n = 2), i.v. | 3 | 55.3 | 34.8 | 90.1 | 92.8 | |
Male dog (n = 2), oral | 6 | 66.2 | 31.4 | 97.6 | 102.7 | |
Female dog (n = 2), i.v. | 3 | 60.0 | 30.7 | 90.7 | 93.9 | |
Female dog (n = 2), oral | 6 | 63.4 | 27.9 | 91.3 | 98.5 | |
Human (n = 3), i.v. | 3 | 76.9 | 25.8 | 102.7 | 104.0 | |
Human (n = 3), oral | 2.4 | 79.8 | 20.2 | 100.0 | 105.0 |