TABLE 3

Enzymes implicated in drug biotransformation/clearance


Clearance Mechanism

Possible Enzymes/Proteins Involved
Oxidative metabolism P450, FMO, MAO, Mo-CO, peroxidases
Hydrolytic metabolism Esterases, amidases, epoxide hydrolases
Conjugative metabolism UGT, ST, methyltransferase, acetyltransferase
Excretion of unchanged drug
Transporters