TABLE 5

Examples of common positive controls and suggested concentrations for in vitro human P450 enzyme induction (LeCluyse et al., 2000; Meunier et al., 2000; Gerbal-Chaloin et al., 2001; Goodwin et al., 2001)


P450

Inducer
CYP1A2 Omeprazole (25 μM), β-naphthoflavone (10-50 μM)
CYP2B6 Rifampicin (10-50 μM), phenobarbital (200-500 μM)
CYP2C9 Rifampicin (10-50 μM), dexamethasone (10-50 μM)
CYP3A4
Rifampicin (10-50 μM), dexamethasone (50 μM)