TABLE 6

Drug-drug interactions due to the inhibition of transport proteins (modified from Ayrton and Morgan, 2001)


Substrate

Inhibitor

Effect

Potential Transport Protein
Digoxin Quinidine, verapamil, itraconazole ↑ Plasma concentrations, ↓ renal clearance P-Glycoprotein; OATP
Fexofenadine Ketoconazole, erythromycin, azithromycin ↑ Plasma concentrations P-Glycoprotein; OATP
Talinolol Verapamil ↑ or ↓ plasma concentrations; ↓ intestinal secretion P-Glycoprotein
Loperamide Quinidine ↑ Central adverse events P-Glycoprotein
Dofetilide, procainamide, levofloxacine Cimetidine ↑ in AUC; ↓ renal clearance OCT; OAT; OATP
Penicillins, ACE inhibitors, antiviral drugs Probenecid ↓ Renal clearance; prolong t1/2 OAT
Paclitaxel
Valspodar
↑ Plasma concentrations
P-Glycoprotein
  • OCT, organic cation transporter; OAT, organic anion transporter; OATP, organic anion transport protein.