Drug | Dose/Regimen | Midazolam Dose | Fold Elevation in Midazolam AUC (GMRa) | Reference |
---|---|---|---|---|
Ketoconazole | 400 mg q.d. × 4 days | 7.5 mg p.o. | 16 | Olkkola et al., 1994 |
Ketoconazole | 3 doses of 200 mg | 6 mg p.o. | 11 | Tsunoda et al., 1999 |
Itraconazole | 200 mg q.d. × 4 days | 7.5 mg p.o. | 11 | Olkkola et al., 1994 |
Mibefradil | 100 mg p.o. | 2 mg p.o. | 8.9 | Veronese et al., 1999 |
Ketoconazole | 200 mg q.d. × 11 days | Not specified | 8.7 | Lam et al., 1999 |
Itraconazole | 200 mg q.d. × 4 days | 15 or 7.5 mg p.o. | 8 | Backman et al., 1998 |
Clarithromycin | 500 mg b.i.d. × 7 days | 3-4 mg p.o. | 7.1 | Gorski et al., 1999 |
Clarithromycin | 500 mg b.i.d. × 7 days | 4 mg p.o. | 7 | Gorski et al., 1998 |
Ketoconazole | 200 mg given simultaneously | 2 mg p.o. | 6.2 | Olkkola et al., 1994 |
Itraconazole | 100 mg q.d. × 4 days | 7.5 mg p.o. | 6 | Ahonen et al., 1995 |
Ketoconazole
|
200 mg given 2 h before
|
2 mg p.o.
|
5
|
Olkkola et al., 1994
|
↵ a GMR, geometric mean ratio.