List of human liver samples
Sample No. | Sex | Age | Known Drug Intake of CYP3A Inducers | 6β-Hydroxylation of Testosterone | CYP3A5 Genotype | Normalized Amount of mRNA | CYP3A4 Protein | CYP3A5 Protein | CYP3A5/(CYP3A4+CYP3A5) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PXR mRNA | CYP3A4 mRNA | CYP3A5 mRNA | CYP3A43 mRNA | ||||||||||||
| yr | pmol/mg/min | arbitrary units | pmol/mg | ||||||||||||
| HL 19 | M | 13 | 1,420 | *3/*3 | 1,614 | 2,538 | 1,646 | 18 | 90.2 | ND | |||||
| HL 21 | M | 65 | glucocorticoids, phenytoin | 5,060 | *3/*3 | 1,834 | 15,484 | 1,426 | 23 | 400.4 | ND | ||||
| HL 25 | F | 52 | 2,000 | *3/*3 | 2,445 | 202,218 | 2,691 | 95 | 491.4 | ND | |||||
| HL 39 | F | 62 | 1,360 | *3/*3 | 354 | 19,663 | 556 | 4 | 158.2 | ND | |||||
| HL 41 | M | 34 | phenobarbital | 370 | *3/*3 | 679 | 21,499 | 2,474 | 18 | 19.3 | ND | ||||
| HL 42 | M | 31 | phenytoin | 2,650 | *3/*3 | 3,965 | 129,315 | 7,102 | 156 | 316.3 | ND | ||||
| HL 43 | M | 41 | 320 | *3/*3 | 842 | 9,198 | 1,404 | 43 | 47.5 | ND | |||||
| HL 46 | M | 1,070 | *3/*3 | 224 | 254 | 352 | 1 | 58.4 | ND | ||||||
| HL 48 | M | 61 | 2,420 | *3/*3 | 1,619 | 219,127 | 3,921 | 123 | 394.1 | ND | |||||
| HL 49 | M | 49 | 980 | *3/*3 | 1,235 | 12,760 | 1,387 | 2 | 92.5 | ND | |||||
| HL 50 | M | 27 | 410 | *3/*3 | 647 | 1,911 | 513 | 2 | 33.5 | ND | |||||
| HL 51 | F | 69 | 980 | *3/*3 | 1,010 | 6,896 | 1,154 | 2 | 227.2 | ND | |||||
| HL 52 | M | 23 | 310 | *3/*3 | 624 | 1,114 | 1,336 | 6 | 15.2 | ND | |||||
| HL 53 | M | 22 | 1,620 | *3/*3 | 2,440 | 46,513 | 1,821 | 9 | 76.6 | ND | |||||
| HL 55 | M | 28 | no drug intake | 1,830 | *3/*3 | 2,710 | 142,441 | 4,489 | 21 | 137.6 | 6.6 | 0.05 | |||
| HL 110 | F | 40 | 2,380 | *1/*3 | 1,327 | 134,709 | 9,703 | 108 | 130.2 | 48.4 | 0.27 | ||||
| HL 112 | F | 66 | no drug intake | 770 | *3/*3 | 3,256 | 103,667 | 3,732 | 60 | 21.5 | ND | ||||
| HL 113 | F | 62 | 2,700 | *3/*3 | 1,697 | 197,839 | 2,358 | 120 | 204.7 | ND | |||||
| HL 115 | F | 34 | no drug intake | 1,090 | *3/*3 | 1,502 | 80,792 | 2,944 | 87 | 22.1 | ND | ||||
| HL 116 | F | 75 | 2,360 | *3/*3 | 2,850 | 169,787 | 5,251 | 220 | 164.4 | ND | |||||
| HL 117 | M | 61 | 1,380 | *3/*3 | 1,583 | 95,982 | 1,841 | 86 | 42.3 | ND | |||||
| HL 118 | M | 56 | no drug intake | 2,610 | *1/*3 | 1,781 | 111,584 | 9,025 | 163 | 289.2 | 42.1 | 0.13 | |||
| HL 119 | M | 70 | 1,480 | *3/*3 | 2,486 | 171,234 | 2,732 | 280 | 375.6 | ND | |||||
| HL 120 | F | 78 | 1,130 | *1/*3 | 1,908 | 108,190 | 13,479 | 78 | 180.8 | 41.4 | 0.19 | ||||
| HL 121 | M | 61 | no drug intake | 1,330 | *3/*3 | 2,687 | 101,726 | 10,315 | 92 | 94.5 | ND | ||||
| HL 122 | M | 63 | no drug intake | 1,230 | *3/*3 | 1,997 | 136,058 | 1,682 | 177 | 153.4 | ND | ||||
| HL 123 | M | 67 | no drug intake | 950 | *3/*3 | 1,823 | 75,588 | 5,203 | 99 | 80.2 | ND | ||||
| HL 124 | M | 62 | no drug intake | 2,290 | *3/*3 | 3,313 | 194,626 | 15,769 | 435 | 284.8 | ND | ||||
| HL 126 | M | 67 | no drug intake | 1,800 | *3/*3 | 3,259 | 170,456 | 8,735 | 364 | 159.4 | ND | ||||
| HL 127 | F | 60 | 1,730 | *3/*3 | 2,351 | 143,248 | 6,878 | 162 | 128.9 | ND | |||||
| HL 128 | F | 68 | 1,630 | *3/*3 | 2,245 | 177,273 | 3,944 | 172 | 471.8 | ND | |||||
| HL 129 | F | 61 | 1,960 | *3/*3 | 2,781 | 158,690 | 2,733 | 59 | 248.7 | ND | |||||
| IIAM 1005941 | M | 63 | 300 | *3/*3 | 3,089 | 1,486 | 3,526 | 16 | ND | ND | |||||
| IIAM 1014941 | M | 41 | methylprednisolon | 100 | *3/*3 | 3,055 | 2,474 | 575 | 1 | ND | ND | ||||
| IIAM 1101931 | F | 41 | 200 | *1/*3 | 1,132 | 5,846 | 8,262 | 3 | 109.2 | 17.9 | 0.14 | ||||
| IIAM 113961 | F | 38 | methylprednisolon, dexamethasone | 8,000 | *3/*3 | 8,382 | 923,857 | 8,755 | 430 | 600.7 | ND | ||||
| IIAM 305951 | M | 32 | 200 | *3/*3 | 89 | 1,357 | 717 | 5 | ND | ND | |||||
| IIAM 306951 | F | 59 | 3,500 | *3/*3 | 3,238 | 197,855 | 5,420 | 84 | 498.4 | ND | |||||
| IIAM 307961 | F | 45 | 600 | *3/*3 | 1,062 | 2,450 | 2,657 | 2 | 33.0 | ND | |||||
| IIAM 308951 | F | 64 | phenytoin | 3,100 | *3/*3 | 2,700 | 33,283 | 2,633 | 24 | 275.1 | ND | ||||
| IIAM 320951 | M | 28 | 600 | *3/*3 | 314 | 5,727 | 4,317 | 5 | 105.5 | ND | |||||
| IIAM 416931 | M | 32 | 400 | *3/*3 | 55 | 68 | 163 | 1 | ND | ND | |||||
| IIAM 523931 | F | 60 | methylprednisolon, phenytoin | 5,100 | *3/*3 | 647 | 70,401 | 1,996 | 46 | 340.5 | ND | ||||
| IIAM 602941 | M | 47 | 2,900 | *3/*3 | 291 | 5,711 | 660 | 4 | 193.8 | ND | |||||
| IIAM 625961 | F | 42 | 600 | *3/*3 | 65 | 329 | 896 | 1 | 148.5 | ND | |||||
| IIAM 628951 | M | 54 |
| 3,000 | *3/*3 | 622 | 17,820 | 415 | 4 | 248.2 | ND |
| |||
ND, not detected