Compound | Enzymes | Human Liver Microsomes | Recombinant Enzymes | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Vmax | S50, Km | n | Vmax | S50, Km | n | ||||||
pmol/min/mg | μM | pmol/min/mg | μM | ||||||||
Estradiol-3-glucuronide | UGT1A1 | 1,670, 810 | 50, 30 | 1.3, 1.3 | 310, 300 | 20, 22 | 1.4, 1.2 | ||||
Buprenorphine | UGT1A1 | 4,900 ± 1,400 | 57 ± 14 | 1.2 ± 0.01 | 2,300, 2,700 | 45, 68 | 1.2, 1.2 | ||||
Ethinylestradiol | UGT1A1 | 1,500, 1,200 | 21, 13 | 1.3, 1.2 | 700, 600 | 11, 9.7 | 1.2, 1.3 | ||||
Anthraflavic Acid | UGT1A1 | 170, 340 | 4, 5 | 1.3, 1.3 | 830, 810 | 12, 9.8 | 1.2, 1.2 | ||||
Naphthol | UGT1A6 | 17,000, 18,000 | 38, 45 | 1.0, 1.0 | 33,000, 27,000 | 78, 67 | 1.0, 1.0 | ||||
Propofol | UGT1A9 | 4,100, 3,500 | 190, 280 | 1.0, 1.0 | 3,200, 2,400 | 28, 45 | 1.0, 1.0 | ||||
Morphine-3-glucuronide | UGT2B7 | 2,500, 2,700 | 1,900, 3,100 | 1.0, 1.0 | 440, 410 | 290, 200 | 1.1, 1.2 | ||||
Morphine-6-glucuronide | UGT2B7 | 160, 140 | 690, 960 | 1.0, 1.0 | 81, 74 | 240, 240 | 1.2, 1.0 | ||||
Androstanediol | UGT2B15 | 6,700, 5,800 | 25, 21 | 1.2, 1.2 | 980, 980 | 16, 13 | 1.1, 1.0 |