Treatment | 6β-Hydroxy Testosterone Formation Rate | ||||||
---|---|---|---|---|---|---|---|
Rat Liver 1
|
Rat Liver 2
| ||||||
pmol/min/mg protein | fold induction | pmol/min/mg protein | fold induction | ||||
Controla | 251 | 1.0 | 673 | 1.0 | |||
PCN, 0.2 μM | 273 | 1.1 | 789 | 1.2 | |||
PCN, 1.0 μM | 619 | 2.5 | 1240 | 1.8 | |||
Phenobarbital, 10 μM | 254 | 1.0 | 759 | 1.1 | |||
Phenobarbital, 100 μM | 386 | 1.5 | 1196 | 1.8 | |||
GW3333, 1.0 μM | 373 | 1.5 | 958 | 1.4 | |||
GW3333, 2.5 μM | 708 | 2.8 | 1522 | 2.3 | |||
GW3333, 5.0 μM* | 1433 | 5.7 | 2453 | 3.6 | |||
GW3333, 10.0 μM* | 1635 | 6.5 | 3875 | 5.8 | |||
GW3333, 25.0 μM | 1628 | 6.5 | 4448 | 6.6 | |||
GW3333, 50.0 μM | 1659 | 6.6 | 4988 | 7.4 | |||
GW6495, 1.0 μM | 369 | 1.5 | 903 | 1.3 | |||
GW6495, 5.0 μM | 511 | 2.0 | 1162 | 1.7 | |||
GW6495, 25.0 μM | 721 | 2.9 | 1903 | 2.8 | |||
GW6495, 100 μM | 733 | 2.9 | 1668 | 2.5 | |||
GI4023, 1.0 μM | 328 | 1.3 | 696 | 1.0 | |||
GI4023, 5.0 μM | 632 | 2.5 | 809 | 1.2 | |||
GI4023, 25.0 μM | 893 | 3.6 | 1234 | 1.8 | |||
GI4023, 100 μM
|
1282
|
5.1
|
3118
|
4.6
|