0.8 mg/kg oral | 8.0 mg/kg oral | 80 mg/kg oral | 0.8 mk/kg i.v. | |
---|---|---|---|---|
Male Rat | ||||
Urine | 57.1 ± 5.4a,b,c, x | 43.7 ± 1.6b,m,x | 43.5 ± 5.0c,m,x | 45.6 ± 3.4a,x |
Feces | 15.2 ± 1.5c,m | 23.4 ± 1.7a,b,c | 15.3 ± 2.6b,n | 18.1 ± 1.5a,y |
Tissues* | 8.85 ± 0.90a,n,y | 11.7 ± 4.2y | 16.9 ± 4.7y | 17.9 ± 4.0a,z |
Female Rat | ||||
Urine | 61.4 ± 4.6b | 62.5 ± 2.0a,m,z | 55.1 ± 0.6a,b,m, z | |
Feces | 19.8 ± 2.6 b,m | 19.8 ± 2.6a | 6.19 ± 0.95a,b,n | |
Tissues | 5.54 ± 0.26a,n,z | 6.84 ± 1.21w | 10.2 ± 1.8a,w | |
Male Mouse | ||||
Urine | 76.1 ± 4.3x | 73.4 ± 12.3x | 84.8 ± 3.0m,x | 77.8 ± 13.7x |
Feces | 19.7 ± 4.3 | 24.4 ± 7.8a,n | 14.9 ± 1.5p | 11.6 ± 2.2a,y |
Tissues | 1.98 ± 0.04a,y | 2.06 ± 0.14b,y | 1.97 ± 0.17c,y | 3.27 ± 0.02a,b,c, z |
Female Mouse | ||||
Urine | 69.7 ± 9.1b | 76.3 ± 6.5a,z | 93.3 ± 1.6a,b,m, z | |
Feces | 16.1 ± 7.0 | 12.5 ± 4.6n | 7.54 ± 2.44p | |
Tissues
|
2.01 ± 0.23a,z
|
2.14 ±
0.15b,w
|
3.06 ±
0.18a,b,w
|
|