Properties of benzbromarone and its analogs
Compound | Ki app a | pKaa | log Pcalca | log D7.0 calc |
|---|---|---|---|---|
| nM | ||||
| 1 benzbromarone | 19.3 ± 7.5 | 4.5 ± 0.6 | 6.6 ± 0.9 | 4.4 |
| 2 | 796 ± 148 | 4.1 ± 0.8 | 4.1 | |
| 3 | 414 ± 84 | 8.35 ± 0.04 | 3.8 ± 0.8 | 3.7 |
| 4 | 232 ± 50 | 6.2 ± 0.9 | 6.2 | |
| 5 | 91 ± 35 | 5.2 ± 0.5 | 7.7 ± 0.9 | 5.4 |
| 6 | 20.2 ± 5.2 | 4.18 ± 0.06 | 5.8 ± 0.8 | 3.7 |
| 7 | 9.7 ± 3.0 | N.D. | 6.1 ± 0.9 | 3.8 |
|
8
|
1.04 ± 0.12
|
5.2 ± 0.4
|
6.1 ± 0.9
|
3.9
|
N.D., not determined.
↵ a Values are listed as mean ± S.D.