TABLE 4

Count of IC 50 values that lie outside of the linear bounds


P450

Censored Probe

Outside Interval

Inside Interval

Both censored

Total
1A2 Conventional 0 7
Fluorescent 3 0 62 72
2C9 Conventional 0 18
Fluorescent 5 0 31 54
2C19 Conventional 0 2
Fluorescent 0 0 25 27
2D6 Conventional 0 3
Fluorescent 0 0 3 6
3A4 Conventional 3 0 26 93
Fluorescent 0 64
Total Conventional 3 30 p = 0.7

Fluorescent
5
64