Parameter | Value | Schedule or Source | Reference |
---|---|---|---|
Erythromycin | |||
Dose | 681,200 (nmol) | t.i.d. | A, B |
Fa · Fg | 0.58 | Unpublished observation | |
fb | 0.16 | H | |
Kp | 1 | assumed | |
Vliver | 2,800 (ml) | ||
Vpv | 70 (ml) | ||
Q | 1,610 (ml/min) | ||
CLint | 2,940 (ml/min) | * | |
ka | 0.011 (min-1) | * | |
CLr | 0 (ml/min) | * | |
Vsys | 18,000 (ml) | * | |
Tlag | 96 (min) | I | |
Clarithromycin | |||
Dose | 334,242, 668,485 (nmol) | b.i.d. | C, D |
Fa · Fg | 1 | * | |
fb | 0.28 | calculated from fu = 0.18, Rb = 0.64 | J, H |
Kp | 1 | assumed | |
Vliver | 2,800 (ml) | ||
Vpv | 70 (ml) | ||
Q | 1,610 (ml/min) | ||
CLint | 2,176 (ml/min) | * | |
ka | 0.018 (min-1) | * | |
CLr | 100 (ml/min) | * | |
Vsys | 100,000 (ml) | * | |
Tlag | 12 (min) | K | |
Azithromycin | |||
Dose | 636,943 (nmol) | o.d. | B, C |
Fa · Fg | 0.86 | L | |
fb | 0.7 | L | |
Kp | 1 | assumed | |
Vliver | 2,800 (ml) | ||
Vpv | 70 (ml) | ||
Q | 1,610 (ml/min) | ||
CLint | 1,800 (ml/min) | * | |
ka | 0.00175 (min-1) | * | |
CLr | 100 (ml/min) | * | |
Vsys
|
24,500 (ml)
|
*
|
|
A, Olkkola et al., 1993; B, Zimmermann et al., 1996; C, Yeates et al., 1996; D, Gorski et al., 1998; H, Benet et al., 1996; I, Birkett et al., 1990; J, Yago et al., 1996; K, Chu et al., 1992; L, Foulds et al., 1990.
↵* Calculated using eqs. 12 to 16 to fit the reported erythromycin (Birkett et al., 1990), clarithromycin (Chu et al., 1992), or azithromycin blood concentration (Foulds et al., 1990).